Liverpool Hospital
Rheumatology

Clinical Trials

Trials that will commence recruiting mid 2019 :

  • A Multicentre, phase 3, randomized, double-blind, placebo-controlled study with an active-reference drug evaluating the efficacy and safety of bimekizumab in the treatment of subjects with active psoriatic arthritis
  •  A Multinational, Prospective, Observational Study of the Effectiveness, Healthcare Resource Utilization and Costs in Patients with Rheumatoid Arthritis Receiving Baricitinib, Targeted Synthetic or Biologic Disease Modifying Therapies

 

The following trials are open for recruitment:

  • A Phase 4 open-label randomized controlled study Comparing the effectiveness of adalimumab Introduction and methotrexate dose escalation in subjects with Psoriatic Arthritis (CONTROL)
  •  A Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial to Evaluate Efficacy and Safety of Lenabasum in Diffuse Cutaneous Systemic Sclerosis (RESOLVE-1)
  • A Multi-Centre Double-Blind Randomised Placebo-Controlled Trial of Oral Anticoagulation with Apixaban in Systemic Sclerosis-Related Pulmonary Arterial Hypertension (SPHInX)
  • Systemic Lupus Erythematosus (SLE) Prospective Observational Cohort Study (SPOCS) Prospective observational cohort of patients with moderate-to-severe SLE to characterize cross-sectional and longitudinal disease activity, treatment patterns and effectiveness, outcomes and comorbidities, healthcare resource utilization, and the impact of SLE on quality of life by type I interferon gene expression (SPOCs)

 

These trials are active but no longer recruiting:

  •  CNTO1959PSA3001: A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Guselkumab Administered Subcutaneously in Subjects with Active Psoriatic Arthritis including those Previously Treated with Biologic Anti-TNF? Agent(s) (DISCOVER-1)
  • An open-label extension trial to assess the long term safety of nintedanib in patients with ‘Systemic Sclerosis associated Interstitial Lung Disease’ (SENSCIS-ON)

 

Studies Completed:

  • 2016-2019: A double blind, randomized, placebo-controlled trial evaluating efficacy and safety of oral nintedanib treatment for at least 52 weeks in patients with ‘Systemic Sclerosis associated Interstitial Lung Disease’ (SENSCIS)
  •  2016-2019: Long-Term Experience with Abatacept SC in Routine Clinical Practice Study (ASCORE)
  • 2015-2018: A Randomized, Double-Blind, Placebo-Controlled Phase II Study to Investigate the Efficacy and Safety of Riociguat in Patients with Diffuse Cutaneous Systemic Sclerosis (dcSSc)
  •  2015-2017: A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Study of Ustekinumab in Subjects with Active Systemic Lupus Erythematosus

 

For more information on any of the trials, please visit

https://www.australianclinicaltrials.gov.au/
 

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Last Updated: 28 March, 2019
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